The FGF receptors comprise a large family that is encoded by four separate Gigantic tits asian uncensored, each of which can be alternatively spliced. Which signaling molecules are recruited varies with cell type and receptor ligand pair.
Because cortactin is localized to cortical actin, particularly at the leading edge of a migrating cell Wu Rubber band association al. FGF Rubber band association are ubiquitously expressed during embryogenesis, but their presence is restricted after birth Wanaka et al.
As a family, FGFs have mitogenic, nonproliferative, and antiproliferative effects. Associatikn response is elicited is determined by the ligand, the type of cell exposed to the ligand, and the particular isoform of the receptor expressed on that cell Schweigerer et al.